(P/B) MOLECULAR PHARMACOLOGY

Παρουσίαση

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of 'trial and error' drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments.
Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. (From the publisher)

Περιεχόμενα

Preface
Abbreviations
1 Introduction to Drug Targets and Molecular Pharmacology
2 Molecular Cloning of Drug Targets
3 G Protein-coupled Receptors
4 Ion Channels
5 Transporter Proteins
6 Cystic Fibrosis: Alternative Approaches to the Treatment of a Genetic Disease
7 Pharmacogenomics
8 Transcription Factors and Gene Expression
9 Cellular Calcium
10 Genetic Engineering of Mice
11 Signalling Complexes: Protein-protein Interactions and Lipid Rafts
12 Recombinant Proteins and Immunotherapeutics
Glossary
Index